Ketamine (Nolvadexine), also known as an enhancer of glutamate, is a drug used primarily to induce and maintain anaesthesia. It causes a deep sleep condition, amnesia, and a slight reduction in pain. Since it works on the neurogenic mesolimbic pathway, ketamine has strong effects without having side effects on the nervous system. The mechanism of action is to induce the effect of GABA on neurons in the brain by binding to GABA transaminase. Ketamine uses a large group of neurons, called the GABAergic inhibitory system neurons, to provide the basis for its central nervous system behaviour. If you would like to learn more about this, please check out California Center for Ketamine Therapy – Ketamine Clinic.
In the treatment of major diseases such as chronic pain, epilepsy, anxiety disorders, Parkinson’s disease, menopausal syndromes, seizures, migraine headaches and intractable pain caused by traumatic injury, rheumatoid arthritis, cystic fibrosis, multiple sclerosis, obsessive-compulsive disorders, schizosaccharide, Parkinson’s disease, dysthymia and attention deficit disorder, ketamine therapy is used Ketamine has also been used in the treatment of patients with opiate analgesics and benzodiazepines for withdrawal symptoms. In patients with AIDS who are undergoing chemotherapy, ketamine has been used in low doses to increase motivation. Depression and mood disorders have also responded to low ketamine doses favourably. Patients with depression and bipolar disorder who respond to at least one form of antidepressant have also been treated with ketamine.
In a number of methods, including intravenous (IV) infusion, intraventricular (IV) infusion, or inhalation, ketamine may be supplied intravenously throughout anaesthetic procedures. In the past few years, the FDA has approved IV and inhalation infusion methods of administration, but their use remains under debate for safety reasons. The administration of the drug through the vein requires intravenous infusion methods, while intraventricular infusion methods use a pump that transfers the drug into the airways. Studies suggest that some mild anaesthetic problems can result from long-term use of ketamine therapy. Long-term trials comparing IV and inhalation infusions with placebo have not been performed, however.